Exosome in Cosmetic

Creative Biolabs is a leading service provider that focuses on cosmetic products development. Now we are proud to provide a series of exsome-related services for our clients all over the world.

Introduction of Exosomes in Cosmetics

Skin is the largest physical and immunological barrier organism that contains cell types, including keratinocytes, fibroblasts, macrophages, as well as adipocytes. Exposure of human skin to the harsh external environment may lead to skin aging, pigmented skin diseases, hair loss, some immune-mediated skin diseases, and connective tissue diseases. Due to the continuous pursuit of anti-aging and good appearance, many skin treatments are dedicated to achieving a commendable balance between medical recovery and beauty needs.

Exosomes are cell-derived nano-scale vesicles that carry various biomolecules, such as proteins, nucleic acids, and lipids. The carried functional protein and genetic information allow exosomes to communicate with neighboring or distant cells. What’s more, exosomes have also been studied in-depth in cell migration, tumor invasion, myocardial repair, and fracture healing. Recent research showed that endogenous exosomes are the key coordinators of shaping the physiological and pathological development of the skin. It can be used as a new treatment plan for the repair and regeneration of skin tissue.

Figure 1. Diagrammatic representation of the skin structure and the molecular composition of exosomes. (Xiong, 2021)

Exosomes in Cutaneous Medical Aesthetics

Scar removal - Scarring is the biological process of wound healing after skin defects extend into the reticular dermis. Adipose-derived MSCs exosomes can inhibit scar formation and accelerate scar repair.
Skin rejuvenation - It is a process in which the skin loses its structural and functional characteristics through a series of physiological changes. ESC-derived exosomes present great potential for cell-free intervention against skin aging.
Pigmentation regulation - The interaction between keratinocytes and melanocytes in the epidermis leads to skin pigmentation. Exosomes can incorporate various membrane proteins and cytosolic components to regulate pigmentation.
Hair growth - Hair loss is the degeneration of hair follicles due to various reasons. Dermal papilla cells-derived exosomes can regulate hair follicle (HF) growth and stimulate the proliferation and differentiation of outer root sheath cells (ORSCs).

Cosmetic Exosomes Services

Equipped with world-leading technology platforms and professional scientific staff, Creative Biolabs is confident in offering the most qualified services and products for our customers all over the world. If you are interested in our products or services, please do not hesitate to contact us for more detailed information.

Reference

Xiong, M.; et al. The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics. Pharmacological research. 2021: 105490.