Human Skin Model for Microflora Protection Test Service

The cosmetic industry has a long history and technological advancements have made them available to the masses. 3D human skin models have become the latest tool for non-animal testing in the skincare and cosmetic market. The human skin model from Creative Biolabs is a laboratory-grown skin test platform to discover the potential effects of skincare products, cosmetics, health products, etc. on human skin. Our comprehensive capabilities allow for a full range of testing.

Human Skin Model for Microflora Protection Test

In humans, there are resident, transient, and temporary resident microflora in the skin. The microbial community has been considered as a component of normal human skin. In general, the host maintains homeostasis between microorganisms and host tissues through a variety of structures, molecules, and mechanisms. The skin microflora has both beneficial and detrimental effects on humans. It also plays an important role in the development and maintenance of the body's immunity. However, some skin micro-organisms contribute to general body odor and always lead to various skin diseases, such as acne, folliculitis, dandruff, pityriasis, pitted keratolysis, as well as pityriasis.

Cosmetic products are developed to achieve specific effects on the skin that may alter the human skin microflora. Preservatives in cosmetic products may remain active on the skin as active ingredients and cause changes in resident microbial communities with continued use of the product. This effect is minimal in the short term, but in the long run it can have unpredictable results. Studies have shown a range of mechanisms by which long-term cosmetic use may affect the microbial community. Although the associated risks are low, detection of these ecological changes is still warranted.

Fig.1 Two possible mechanisms by which a topical product may influence the resident microflora. (Holland, 2022)

Based on our novel human skin models, it is possible to show the effect of cosmetic products formulation or ingredients on the microflora of the skin. What’s more, we can also colonize specific strains on the skin models to meet the specific needs of your products.

The Resident Microflora in Human Skin

Propionibacterium
Corynebacterium
Brevibacterium
Staphylococcus
Micrococcus
Kytococcus
Dermatococcus
Malassezia furfur

Advantages of our Test Service

Comply with all applicable regulations and ethics.
As an alternative to animal testing.
Better predictability due to the use of live human skin.
More human-specific.
Customized services to meet your special project needs.

Equipped with world-leading technology platforms and professional scientific staff, we are pleased to offer the most qualified services and products for our customers all over the world. If you are interested in our products or services, please do not hesitate to contact us for more detailed information.

Reference

Holland, K.; Bojar, R. Cosmetics. American journal of clinical dermatology. 2002, 3(7): 445-449.