Creative Biolabs is an internationally operating testing laboratory that provides a series of toxicology test services for cosmetic products. Our comprehensive safety testing capabilities meet the international regulatory requirements for cosmetic products. Now we provide multiple methods for endocrine disruptor activity testing.

The Introduction of Endocrine Disrupting Chemicals (EDCs)

Endocrine disrupting chemicals (EDCs) are chemical substances that can destroy the endocrine system. The endocrine system involves complex organs such as the brain and sexual organs (ovaries or testes). These organs cooperate and transmit information through hormones. And the EDCs can also be understood as hormones. When EDCs enter the bloodstream through skin or intestinal absorption, they may mimic estrogen and replicate the effects of testosterone to bring a series of reproductive and developmental effects.

Endocrine Disrupting Chemicals (EDCs) in Cosmetic Products

• Parabens - Parabens have the effect of imitating estrogen in the body. Some studies believe that it will increase the risk of diseases such as breast cancer and testicular cancer.
• Phthalates - Phthalates can inhibit testosterone in the body, reduce semen quality, and negatively affect male genital development. Studies have shown that pregnant women who are exposed to a large number of phthalates may have miscarriage and pregnancy complications.
• Bisphenol A (BPA) - BPA has the properties of estrogen, which may affect the growth and development of infants and young children, and cause damage to children's brain and sexual organs.
• Fragrances - In addition to the possibility of causing reproductive toxicity, fragrances can cause problems such as eczema, asthma, worsening asthma, and headaches.
• Glycol Ethers - Glycol ether can reduce sperm motility and negatively affect red blood cells, causing permanent damage to the blood circulatory system and nervous system of the human body. In addition, such substances can cause harm to female reproduction.
• Cyclosiloxanes - Cyclosiloxanes have weak estrogenic effects, which may affect the production of breast milk and may cause some health problems for babies.
• Benzones - Benzones may be related to precocious puberty in women, low sperm motility in men, and infertility.

Methods for Endocrine Disruptor Activity Test

• Steroidogenesis assay using H295R cells (OECD 456)
• Androgen receptor binding assay using cytosol of prostate (OPPTS 890.1150)
• Estrogen receptor binding assay using cytosol of uteri (OPPTS 1250)
• Aromatase assay using human supersomes (OPPTS 890.1200)
• Transcriptional estrogen receptor binding assay using HeLa cells (OPPTS 890.1300)

Equipped with world-leading technology platforms and professional scientific staff, we are pleased to offer the most qualified services and products for our customers all over the world. If you are interested in our products or services, please do not hesitate to contact us for more detailed information.

• Cytotoxicity Test
• Skin Irritation/Corrosion Test
• Eye Irritation/Corrosion Test
• Skin Sensitization Test
• Genetic Toxicity Test
• Phototoxicity Test
• Skin Penetration Test
• Reproductive Toxicity Test
• Carcinogenicity Test