Creative Biolabs is an internationally operating testing laboratory that provides a series of toxicology test services for cosmetic products. Our comprehensive safety testing capabilities meet the international regulatory requirements for cosmetic products. Now we provide multiple methods for skin irritation/corrosion testing.

The Necessary of Skin Irritation/Corrosion Test

In recent years, the cosmetics industry is developing rapidly, but it is also accompanied by stricter regulatory mechanisms. Of course, cosmetic manufacturers hope that their products will not irritate the skin. Unfortunately, many ingredients (such as surfactants, preservatives, emulsifiers, and many other organic substances) are inherently irritating.

As part of a basic cosmetic toxicology test program, the evaluation of the potential of a chemical that leads to skin irritation/corrosion must be assessed. Skin irritation refers to the reversible damage to the skin following the application of a test substance for up to 4 hours, while skin corrosion is defined as the irreversible damage to the skin following the application of a test substance for 3 mins up to 4 hours. Historically, rabbit is a powerful tool for cosmetics skin irritation/corrosion tests. However, due to differences in skin structure between humans and rabbits, as well as the cessation of animal testing of cosmetic ingredients specified in the Cosmetics Directive, alternative methods are urgently needed.

Introduction of RHE Models for Irritation/Corrosion Test

Nowadays, a series of alternative assays have been developed to determine the skin irritation/corrosion potential of cosmetics, especially the use of reconstructed human epidermis (RHE) in vitro skin models. In RHE skin models, keratinocytes play important roles in the initiation, modulation, and regulation of skin irritation. In this case, the functional stratum corneum allows the test of neat chemicals added directly to the stratum corneum. Compared with normal human skin, RHE models present higher penetration and sensitivity.

Alternative Approaches to the Assessment of Skin Irritation/Corrosion

• Analysis of physicochemical properties.
• In silico methods.
• Historical in vivo animal data.
• Human clinical data.
• In vitro research and data.

Advantages of our Skin Irritation/Corrosion Test

• No use animals to avoid ethical and legal issues
• Various RHE models for different purposes
• Highly sensitive to irritants
• Low cost with fast results
• Customized services to meet various needs

Equipped with world-leading technology platforms and professional scientific staff, we are pleased to offer the most qualified services and products for our customers all over the world. If you are interested in our products or services, please do not hesitate to contact us for more detailed information.

• Cytotoxicity Test
• Eye Irritation/Corrosion Test
• Skin Sensitization Test
• Genetic Toxicity Test
• Phototoxicity Test
• Skin Penetration Test
• Endocrine Disruptor Activity Test
• Reproductive Toxicity Test
• Carcinogenicity Test