Reproductive Toxicity Test Service

Creative Biolabs is an internationally operating testing laboratory that provides a series of toxicology test services for cosmetic products. Our comprehensive safety testing capabilities meet the international regulatory requirements for cosmetic products. Now we provide multiple methods for reproductive toxicity testing.

The Introduction of Reproductive Toxicity

Reproductive toxicity is the process by which certain reproductive toxic substances interfere with normal reproduction in some way. It may adversely affect the sexual function and fertility of adult men and women, and cause developmental toxicity in offspring. According to reports, 3% of human newborns are affected by congenital anomalies, 5-10% of which are due to severe side effects of chemical compounds. In this case, the toxicological safety assessment of any cosmetic products or drugs is necessary for humans, especially pregnant women.

Preclinical Reproductive Toxicity Testing

Fertility
Embryotoxicity/teratogenicity
prenatal and postnatal toxicity

Methods for Reproductive Toxicity Testing

The complexity of the reproductive system and the large number of tissue targets that induce deformities or postpartum effects provide a basis for the toxicity testing of chemicals in highly standardized and internationally recognized tests. Following OECD guidelines, there are both in vivo and in vitro reproductive toxicity tests. The in vivo tests are always more time-consuming, expensive, and raise ethical issues. In this case, various in vitro methods have been developed, such as whole embryo culture (WEC), Xenopus (FETAX) test, or chicken (CHEST).

Among them, the animal-free, cell-line-based embryonic stem cell test (EST) has been the most extensively studied test. Established from the inner cell mass, embryonic stem (ES) cell lines can be expanded under the control conditions and remain pluripotent. In the field of toxicology, the embryonic mouse stem cell has been used for reproductive toxicity tests. Creative Biolabs now provides the embryonic mouse stem cell test (EST) for reproductive toxicity testing in cosmetic products.

Advantages of our Reproductive Toxicity Test

No uses animals to avoid ethical and legal issues.
A sufficient number of tissue-specific cells can be provided.
Exhibit key cellular characteristics and generalize normal human biology.
Low price with good service.
Customized services to meet various needs.

Equipped with world-leading technology platforms and professional scientific staff, we are pleased to offer the most qualified services and products for our customers all over the world. If you are interested in our products or services, please do not hesitate to contact us for more detailed information.

Reference

Pickles, J.; et al. A mechanistic evaluation of the Syrian hamster embryo cell transformation assay (pH 6.7) and molecular events leading to senescence bypass in SHE cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2016, 802: 50-58.